Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 33
Filter
1.
Sci Rep ; 14(1): 7175, 2024 Mar 26.
Article in English | MEDLINE | ID: mdl-38532041

ABSTRACT

The Mars Sample Return mission intends to retrieve a sealed collection of rocks, regolith, and atmosphere sampled from Jezero Crater, Mars, by the NASA Perseverance rover mission. For all life-related research, it is necessary to evaluate water availability in the samples and on Mars. Within the first Martian year, Perseverance has acquired an estimated total mass of 355 g of rocks and regolith, and 38 µmoles of Martian atmospheric gas. Using in-situ observations acquired by the Perseverance rover, we show that the present-day environmental conditions at Jezero allow for the hydration of sulfates, chlorides, and perchlorates and the occasional formation of frost as well as a diurnal atmospheric-surface water exchange of 0.5-10 g water per m2 (assuming a well-mixed atmosphere). At night, when the temperature drops below 190 K, the surface water activity can exceed 0.5, the lowest limit for cell reproduction. During the day, when the temperature is above the cell replication limit of 245 K, water activity is less than 0.02. The environmental conditions at the surface of Jezero Crater, where these samples were acquired, are incompatible with the cell replication limits currently known on Earth.

2.
Sci Total Environ ; 921: 171074, 2024 Apr 15.
Article in English | MEDLINE | ID: mdl-38378059

ABSTRACT

Septic tank systems (STS) in rural catchments represent a potential source of microbial pollution to watercourses; however, data concerning the risk of faecal indicator organism (FIO) export from STS to surface waters are scarce. In the absence of empirical data, elicitation of expert judgements can provide an alternative approach to aid understanding of FIO pollution risk from STS. Our study employed a structured elicitation process using the Sheffield Elicitation Framework to obtain expert judgements on the proportion of FIOs likely to be delivered from STS to watercourses, based on 36 scenarios combining: (i) septic tank effluent movement risk, driven by soil hydro-morphological characteristics; (ii) distance of septic tank to watercourse; and (iii) degree of slope. Experts used the tertile method to elicit a range of values representing their beliefs of the proportion of FIOs likely to be delivered to a watercourse for each scenario. The experts judged that 93 % of FIOs would likely be delivered from an STS to a watercourse under the highest risk scenario that combined (i) very high STS effluent movement risk, (ii) STS distance to watercourse <10 m, and (iii) a location on a steep slope with gradient >25 %. Under the lowest risk scenario, the proportion of FIOs reaching a watercourse would likely reduce to 5 %. Expert confidence was high for scenarios that represented extremes of risk, while uncertainty increased for scenarios depicting intermediate risk conditions. The behavioural aggregation process employed to obtain a consensus among the experts proved to be useful for highlighting both areas of strong consensus and high uncertainty. The latter therefore represent priorities for future empirical research to further improve our understanding of potential pollution risk from septic tanks and in turn enable better assessments of potential threats to water quality in rural catchments throughout the world where decentralised wastewater systems are common.


Subject(s)
Judgment , Water Quality , Feces
3.
J Adv Nurs ; 80(3): 1201-1211, 2024 Mar.
Article in English | MEDLINE | ID: mdl-37771198

ABSTRACT

AIMS: The aims of the study were to determine the types and prevalence of forensic mental health nurse exposure to patient aggression and explore the impact of these exposures on their physical and mental health and work absences. DESIGN: Cross-sectional survey conducted January to April 2020. METHODS: All 205 nurses working in an Australian high-security inpatient forensic mental health hospital were invited to participate. An online survey included the Perception of Prevalence of Aggression Scale to measure respondent exposure to types of patient aggression, and the SF-36v2 to measure mental and physical health. Absence from work and other work and individual characteristics were also explored. RESULTS: Sixty-eight respondents completed the survey. Verbal abuse was the most experienced aggression type, followed by physical violence and observing violence, patient self-harming behaviours and sexual violence. Nurses who worked in acute units experienced significantly more exposure to overall aggression than nurses in non-acute units. Higher level of aggression was associated with number of days sick leave taken and days off due to aggression or violence. Higher level of aggression was associated with poorer mental health, and patient self-harming behaviour was associated with poorer physical health. CONCLUSIONS: Nurses in acute units experience higher levels of inpatient aggression and are therefore at increased risk of being impacted by the exposure. Findings indicate a psychological impact of exposure to frequent aggression and potential for an accumulative effect of exposure to traumatic events on nurse well-being. Nurses who are victim of, or witness, physical violence are most likely to take time off work. IMPACT: This study provides further evidence that forensic mental health nurses are frequently exposed to various forms of patient aggression. For some nurses, this exposure to patient aggression negatively impacted their mental and physical health. Employing organizations should therefore prioritize provision of formal support for nurses. No patient or public contribution.


Subject(s)
Aggression , Workplace Violence , Humans , Aggression/psychology , Cross-Sectional Studies , Mental Health , Australia/epidemiology , Surveys and Questionnaires , Outcome Assessment, Health Care , Workplace Violence/psychology
4.
J Forensic Nurs ; 2023 Sep 26.
Article in English | MEDLINE | ID: mdl-37749791

ABSTRACT

BACKGROUND: Nurses working in forensic mental health settings are at risk of vicarious trauma because of their exposure to traumatized patients and distressing material such as the aversive details of patient crimes. AIM: The aim of this study was to determine the incidence of vicarious trauma and explore its impact on health and absence from work. METHODS: A cross-sectional descriptive correlational study was undertaken. All 205 forensic mental health nurses working in a high-security inpatient facility were invited to participate. An online survey included the Vicarious Trauma Scale and the SF-36v2 to measure mental and physical health. Absence from work was also explored. RESULTS: Sixty-seven respondents completed the survey. Almost half of respondents had a moderate level of vicarious trauma, and only over one-quarter experienced high levels. Higher levels of vicarious trauma were associated with poorer mental health (r = -0.59, p < 0.000) and absence from work (r = 0.27, p < 0.010). CONCLUSIONS: Forensic mental health nurses are at a greater risk of vicarious trauma than nurses working in mainstream mental health services, given their exposure to aversive details of patients' violent crimes. Adverse mental health consequences of vicarious trauma, and other forms of workplace trauma experienced by forensic mental health nurses, are likely to include trauma-related symptoms, depression, and anxiety. Forensic mental health nurses experiencing vicarious trauma may use sick leave as time away from work to care for their own mental health or a coping mechanism for workplace-induced psychological distress.

5.
J Hum Genet ; 68(9): 643-648, 2023 Sep.
Article in English | MEDLINE | ID: mdl-37268768

ABSTRACT

The RNA-binding motif protein 10, RBM10, is an RNA splicing regulator essential for development. Loss-of-function RBM10 variants are associated with TARP syndrome, a severe X-linked recessive condition in males. We report a 3-year-old male with a mild phenotype, consisting of cleft palate, hypotonia, developmental delay, and minor dysmorphisms, associated with a missense RBM10 variant, c.943T>C, p.Ser315Pro, affecting the RRM2 RNA-binding domain. His clinical features were similar to a previously reported case associated with a missense variant. The p.Ser315Pro mutant protein was expressed normally in the nucleus, but its expression level and protein stability were slightly reduced. Nuclear magnetic resonance spectroscopy showed that the structure and the RNA-binding ability of the RRM2 domain with the p.Ser315Pro were unaffected. However, it affects the alternative splicing regulations of downstream genes, NUMB and TNRC6A, and its splicing alteration patterns were variable depending on target transcripts. In summary, a novel germline missense RBM10 p.Ser315Pro variant that causes functional changes in the expression of its downstream genes results in a non-lethal phenotype associated with developmental delays. The functional alteration effects depend on the residues affected by missense variants. Our findings are expected to bring broader insights into the RBM10-associated genotype-phenotype relationships by delineating the molecular mechanism of RBM10 functions.


Subject(s)
Alternative Splicing , Neurodevelopmental Disorders , Male , Humans , RNA Splicing , RNA-Binding Proteins/genetics , RNA-Binding Proteins/metabolism , Mutation, Missense , Neurodevelopmental Disorders/genetics
6.
J Forensic Nurs ; 19(1): 12-20, 2023.
Article in English | MEDLINE | ID: mdl-35271525

ABSTRACT

BACKGROUND: Clinical supervision may support forensic mental health nurses with personal and professional growth in a work environment characterized by therapeutic, ethical, and practical challenges. AIM: The aim of this study was to describe the experiences of forensic mental health nurses participating in a clinical supervision program. METHODS: Seven forensic mental health nurses and two allied health professionals, working in a high-security forensic mental health hospital, were interviewed regarding their experiences of participating in a clinical supervision program. FINDINGS: Participants expressed a need for clinical supervision and were motivated to participate in the program. Benefits of clinical supervision experienced by participants included improved communication with their colleagues, being supported in their career development, and developing habits and techniques to reflect on practice issues. Participants described being able to connect with their supervisor, enabled by both trust and confidence in the supervisor's expertise. CONCLUSION: Staff showed engagement in the clinical supervision process and expressed experiencing positive outcomes related to personal and professional growth and development. IMPLICATIONS FOR CLINICAL FORENSIC NURSING PRACTICE: To support nurses with the forensic mental health context-specific challenges they face, organizations should enable and promote access to clinical supervision. Considerations for forensic mental health organizations to increase uptake and effectiveness of clinical supervision include use of externally based clinical supervisors with adequate skills and experience with providing clinical supervision to clinical staff who work in a secure environment.


Subject(s)
Nurses , Psychiatric Nursing , Humans , Mental Health , Preceptorship , Hospitals, Psychiatric , Clinical Competence
7.
J Geophys Res Planets ; 127(6): e2021JE007096, 2022 Jun.
Article in English | MEDLINE | ID: mdl-35865672

ABSTRACT

Gale crater, the field site for NASA's Mars Science Laboratory Curiosity rover, contains a diverse and extensive record of aeolian deposition and erosion. This study focuses on a series of regularly spaced, curvilinear, and sometimes branching bedrock ridges that occur within the Glen Torridon region on the lower northwest flank of Aeolis Mons, the central mound within Gale crater. During Curiosity's exploration of Glen Torridon between sols ∼2300-3080, the rover drove through this field of ridges, providing the opportunity for in situ observation of these features. This study uses orbiter and rover data to characterize ridge morphology, spatial distribution, compositional and material properties, and association with other aeolian features in the area. Based on these observations, we find that the Glen Torridon ridges are consistent with an origin as wind-eroded bedrock ridges, carved during the exhumation of Mount Sharp. Erosional features like the Glen Torridon ridges observed elsewhere on Mars, termed periodic bedrock ridges (PBRs), have been interpreted to form transverse to the dominant wind direction. The size and morphology of the Glen Torridon PBRs are consistent with transverse formative winds, but the orientation of nearby aeolian bedforms and bedrock erosional features raise the possibility of PBR formation by a net northeasterly wind regime. Although several formation models for the Glen Torridon PBRs are still under consideration, and questions persist about the nature of PBR-forming paleowinds, the presence of PBRs at this site provides important constraints on the depositional and erosional history of Gale crater.

8.
Sci Adv ; 8(21): eabn3783, 2022 May 27.
Article in English | MEDLINE | ID: mdl-35613267

ABSTRACT

Despite the importance of sand and dust to Mars geomorphology, weather, and exploration, the processes that move sand and that raise dust to maintain Mars' ubiquitous dust haze and to produce dust storms have not been well quantified in situ, with missions lacking either the necessary sensors or a sufficiently active aeolian environment. Perseverance rover's novel environmental sensors and Jezero crater's dusty environment remedy this. In Perseverance's first 216 sols, four convective vortices raised dust locally, while, on average, four passed the rover daily, over 25% of which were significantly dusty ("dust devils"). More rarely, dust lifting by nonvortex wind gusts was produced by daytime convection cells advected over the crater by strong regional daytime upslope winds, which also control aeolian surface features. One such event covered 10 times more area than the largest dust devil, suggesting that dust devils and wind gusts could raise equal amounts of dust under nonstorm conditions.

9.
Int J Nurs Stud ; 117: 103897, 2021 May.
Article in English | MEDLINE | ID: mdl-33647844

ABSTRACT

BACKGROUND: Forensic mental health is a challenging workplace, with nurses subject to various trauma exposures in their professional role. OBJECTIVES: To identify the key concepts related to the nature, extent and impact of workplace trauma for forensic mental health nurses. DESIGN: A scoping review, informed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) tool. METHODS: Sources of evidence were identified and assessed for inclusion using an explicit search strategy. Relevant information was extracted and synthesised to present a descriptive summary of existing evidence. RESULTS: Of the 16 articles on workplace trauma for forensic mental health nurses included in the review, nine reported data related to extent (incidence and severity) and 14 described the impact. The incidence (per bed/per year) of each workplace trauma type ranged from 0.95 - 7.15 for physical violence, 0.39-5.12 for verbal abuse, 0.03-0.12 for sexual violence, and 1.47-7.9 for self-harming behaviour. The proportion of incidents at the lowest severity rating ranged from 15.1% to 84.7%, and the range for the highest severity rating was 0% to 38.7%. In the single study that examined the incidence of vicarious trauma, 14.9% reported low levels and 27.7% reported high levels. Psychological distress was the most commonly reported impact of workplace trauma, identified in eight studies. Seven studies reported limited data for physical injury from workplace trauma. The impacts of exposure to workplace trauma reported in the remaining studies included needing to access psychological support, experiencing physiological symptoms, feeling less safe at work, and requiring time off work. With the exception of two studies providing limited data related to absenteeism, the impact for organisations was not explored in existing literature. CONCLUSIONS: While studies indicated that forensic mental health nurses are frequently exposed to various forms of workplace trauma, reports of severe assaults on staff were rare. Although limited, these findings suggest that cumulative exposure to workplace trauma over time, or exposure to more severe forms of physical violence, increase forensic mental health nurse vulnerability to experiencing detrimental impacts on their personal and professional wellbeing.


Subject(s)
Nurses , Psychiatric Nursing , Aggression , Humans , Mental Health , Workplace
10.
Contemp Nurse ; 56(4): 354-362, 2020 Aug.
Article in English | MEDLINE | ID: mdl-33054641

ABSTRACT

Background: Little is known about the personal, professional and workplace factors that influence evidence-based practice for forensic mental health nurses. Aim: This study describes the sources of practice knowledge for forensic mental health nurses, and the factors that influence the implementation of evidence-based practice. Design: This research study utilised a cross sectional survey design. Methods: All nurses (n = 244) working in one forensic mental health in-patient facility were sent an electronic invitation to complete the Developing Evidence Based Practice Questionnaire. Data was analysed to calculate descriptive statistics. Findings: Fifty-three respondents completed the survey. Respondents reported using experiential knowledge and locally derived sources of information more frequently than research-based evidence to inform their practice. Respondents reported being least skilled at finding, reviewing and using research evidence to change practice. The most frequently rated barriers to evidence-based practice were having insufficient time and resources to both finding and reviewing information and to implement changes in practice. Conclusions: Forensic mental health nurses tend to express a bias towards valuing social or qualitative sources of information to inform practice. Exploring the relationships between individual and organisational factors in the context of forensic mental health is recommended in order to gain further insights into the translation of evidence into practice for forensic mental health nurses. Impact statement: Unique contextual aspects of the forensic mental health environment may influence the implementation of evidence-based practice. Our study highlights that further support, resources and training is required to promote the use of research-based evidence in forensic mental health nursing.


Subject(s)
Attitude of Health Personnel , Evidence-Based Nursing/organization & administration , Forensic Nursing/organization & administration , Health Knowledge, Attitudes, Practice , Nursing Staff, Hospital/psychology , Psychiatric Nursing/organization & administration , Adult , Cross-Sectional Studies , Evidence-Based Nursing/methods , Female , Forensic Nursing/methods , Humans , Male , Middle Aged , New South Wales , Psychiatric Nursing/methods , Surveys and Questionnaires
11.
J Forensic Nurs ; 16(3): 161-168, 2020.
Article in English | MEDLINE | ID: mdl-31977515

ABSTRACT

BACKGROUND: Although it is known that forensic mental health nurses (FMHNs) work in a stressful environment, their experience of stress and burnout remains largely unexplored. AIM: The study aimed to measure levels of burnout and workplace stressors experienced by FMHNs. METHODS: A survey of 205 FMHNs was undertaken. Respondents completed the Maslach Burnout Inventory and the Nursing Stress Scale. FINDINGS: Fifty-seven FMHNs completed the survey, representing a response rate of 27.8%. Only five respondents (8.8%) experienced high levels of burnout across all three Maslach Burnout Inventory subscales. The most reported workplace stressors were related to "workload," "conflict with other nurses," and "conflict with physicians." A correlation between total Nursing Stress Scale score and both "emotional exhaustion" and "cynicism" were found (r = 0.45, p < 0.001, and r = 0.34, p < 0.011, respectively), indicating that FMHNs who reported higher workplace stress are at an increased risk of burnout. CONCLUSION: Most FMHNs in the current study experienced moderate levels of burnout, although they continued to feel self-assured in their practice and found their work rewarding. Consistent with other nursing populations, the FMHNs in this study reported feeling stressed by their workload and as the result of conflict with other nurses and physicians. IMPLICATIONS FOR CLINICAL FORENSIC NURSING PRACTICE: Reduced well-being, associated with stress and burnout, may lead to increased absences from work and the delivery of poor-quality forensic mental health consumer care. The implementation of staff well-being strategies is recommended to address stress and burnout in FMHNs.


Subject(s)
Burnout, Professional/epidemiology , Nursing Staff, Hospital/psychology , Occupational Stress/epidemiology , Psychiatric Nursing , Adult , Female , Hospitals, Psychiatric , Humans , Interprofessional Relations , Male , New South Wales/epidemiology , Nursing Staff, Hospital/statistics & numerical data , Physician-Nurse Relations , Sampling Studies , Surveys and Questionnaires , Workload
12.
J Forensic Nurs ; 15(3): 183-192, 2019.
Article in English | MEDLINE | ID: mdl-31259816

ABSTRACT

BACKGROUND: Correctional health and forensic mental health (FMH) staff may experience vicarious trauma (VT) as a result of cumulative and repeated exposure to traumatic material in their professional roles. AIM: This study aimed to determine the incidence of VT in a sample of correctional health and FMH staff. METHODS: A cross-sectional survey including 135 correctional health and FMH staff participating in a VT management program was conducted. Survey respondents completed the Vicarious Trauma Scale and Impacts of Events Scale-Revised. FINDINGS: Most respondents had moderate or high VT (n = 78, 57.8%, and n = 40, 29.6%, respectively). Low psychological distress was reported, with posttraumatic stress disorder symptoms being experienced either mildly or not at all by most respondents. A significant relationship between total Vicarious Trauma Scale score and total Impacts of Events Scale-Revised score (r = 0.471, p = 0.000) was found, indicating that a higher level of VT was associated with an increased risk of posttraumatic stress disorder symptoms. A higher level of VT was also associated with increased reports of avoidance, intrusion, and hyperarousal (r = 0.382, p = 0.000; r = 0.489, p = 0.000; and r = 0.440, p = 0.000, respectively). CONCLUSION: Correctional health and FMH staff are at risk of developing VT and associated psychological distress. IMPLICATIONS FOR CLINICAL FMH NURSING PRACTICE: Correctional health and FMH organizations have the responsibility to ensure nurses are aware of the effects of VT and to provide opportunities for nurses to participate in VT education and management programs.


Subject(s)
Nursing Staff/psychology , Occupational Diseases/epidemiology , Psychological Distress , Stress Disorders, Post-Traumatic/epidemiology , Adult , Cross-Sectional Studies , Female , Hospitals, Psychiatric , Humans , Male , Middle Aged , New South Wales/epidemiology , Prisons , Surveys and Questionnaires
13.
Icarus ; 329: 197-206, 2019 Sep 01.
Article in English | MEDLINE | ID: mdl-31359883

ABSTRACT

This paper updates the record of atmospheric dust loading within northern Gale Crater, Mars, by providing line-of-sight extinction (LOS-Ext) measurements of the intervening dust between the rover and the crater rim. These measurements are derived from images taken with the Navigation Cameras (Navcam) onboard the Mars Science Laboratory (MSL) rover, Curiosity. The observations span 2.44 Mars years, from Mars Year (MY) 31 at a solar longitude (L S ) of 208° to t L S = 7° of MY34, sols 100 - 1701 of the MSL surface mission. This work examines the dataset for seasonal trends of the LOS-Ext in addition to horizontal variations and the vertical structure of LOS-Ext. The LOS-Ext has a repetitive pattern with a single peak in the latter half of the Mars year. The atmosphere in the crater is well mixed horizontally but not vertically as larger LOS-Ext is seen nearer the crater floor than at higher altitudes within the crater. The results allow a discussion on whether or not Gale Crater is a sink for atmospheric dust or a source of atmospheric dust in the current era.

14.
Int J Prison Health ; 15(1): 24-36, 2019 03 11.
Article in English | MEDLINE | ID: mdl-30827163

ABSTRACT

PURPOSE: The purpose of this paper is to identify and deliberate the service development needs required for the improvement of service provision for incarcerated adults with autism spectrum disorder (ASD) in NSW, Australia. DESIGN/METHODOLOGY/APPROACH: Consultation groups were conducted to bring together n=5 key stakeholders from heath and correctional-based services in the prison system. A facilitated asynchronous e-mail-based discussion occurred amongst group members between consultation group meetings. FINDINGS: Two main themes were identified: detecting persons with ASD and providing appropriate care. Participants discussed current service gaps with regard to the identification of people with ASD at the point of contact with the prison service, and the difficulties associated with diagnosing prisoners with ASD. The need for effective alert systems to detect persons with ASD in custody was identified. The current absence of ASD-specific support services in prison was highlighted, and recommendations for improvement suggested. PRACTICAL IMPLICATIONS: Current health and correctional-based service provision failed to adequately support incarcerated adults with ASD. Improvements in prison-entry screening processes, alert systems and diagnostic practices are required. Multidisciplinary collaboration between prison-based and external service providers is required for the development of a model of care based on individualised case management to adequately support incarcerated adults with ASD in prison. ORIGINALITY/VALUE: Given the lack of reported service provision for incarcerated adults with ASD internationally, other prison-based services are likely to experience similar service development needs and see the relevance of the recommendations made directly from the study findings.


Subject(s)
Autism Spectrum Disorder/diagnosis , Autism Spectrum Disorder/therapy , Needs Assessment/organization & administration , Prisons/organization & administration , Autism Spectrum Disorder/epidemiology , Humans , New South Wales , Prisoners
15.
ChemistryOpen ; 6(4): 585-598, 2017 08.
Article in English | MEDLINE | ID: mdl-28794954

ABSTRACT

A cationic bis-imidazolium-based amphiphile was used to form thermoreversible nanostructured supramolecular hydrogels incorporating neutral and cationic drugs for the topical treatment of rosacea. The concentration of the gelator and the type and concentration of the drug incorporated were found to be factors that strongly influenced the gelling temperature, gel-formation period, and overall stability and morphology. The incorporation of brimonidine tartrate resulted in the formation of the most homogeneous material of the three drugs explored, whereas the incorporation of betamethasone resulted in a gel with a completely different morphology comprising linked particles. NMR spectroscopy studies proved that these gels kept the drug not only at the interstitial space but also within the fibers. Due to the design of the gelator, drug release was up to 10 times faster and retention of the drug within the skin was up to 20 times more effective than that observed for commercial products. Experiments in vivo demonstrated the rapid efficacy of these gels in reducing erythema, especially in the case of the gel with brimonidine. The lack of coulombic attraction between the gelator-host and the guest-drug seemed particularly important in highly effective release, and the intermolecular interactions operating between them were found to lie at the root of the excellent properties of the materials for topical delivery and treatment of rosacea.

16.
J Exp Biol ; 220(Pt 18): 3344-3354, 2017 09 15.
Article in English | MEDLINE | ID: mdl-28705828

ABSTRACT

The ability to survive and reproduce after cold exposure is important in all kingdoms of life. However, even in a sophisticated genetic model system like Drosophila melanogaster, few genes have been identified as functioning in cold tolerance. The accumulation of the Frost (Fst) gene transcript increases after cold exposure, making it a good candidate for a gene that has a role in cold tolerance. Despite extensive RNAi knockdown analysis, no role in cold tolerance has been assigned to Fst CRISPR is an effective technique for completely knocking down genes, and is less likely to produce off-target effects than GAL4-UAS RNAi systems. We have used CRISPR-mediated homologous recombination to generate Fst-null alleles, and these Fst alleles uncovered a requirement for FST protein in maintaining female fecundity following cold exposure. However, FST does not have a direct role in survival following cold exposure. FST mRNA accumulates in the Malpighian tubules, and the FST protein is a highly disordered protein with a putative signal peptide for export from the cell. Future work is needed to determine whether FST is exported from the Malpighian tubules and directly interacts with female reproductive tissues post-cold exposure, or whether it is required for other repair/recovery functions that indirectly alter energy allocation to reproduction.


Subject(s)
CRISPR-Cas Systems , Drosophila Proteins/genetics , Drosophila melanogaster/physiology , Gene Expression , Animals , Cold Temperature , Drosophila Proteins/metabolism , Female , Loss of Function Mutation , Male , Malpighian Tubules/metabolism , Recombinant Proteins/genetics , Recombinant Proteins/metabolism , Reproduction
17.
Chem Commun (Camb) ; 53(32): 4509-4512, 2017 Apr 18.
Article in English | MEDLINE | ID: mdl-28387417

ABSTRACT

Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug release from the gel. Drug release and skin permeation experiments show its potential for topical administration.


Subject(s)
Hydrogels/pharmacology , Imidazoles/pharmacology , Serine Proteinase Inhibitors/pharmacology , Skin/drug effects , Administration, Topical , Cations/administration & dosage , Cations/chemistry , Cations/pharmacology , Drug Liberation/drug effects , Humans , Hydrogels/administration & dosage , Hydrogels/chemistry , Imidazoles/administration & dosage , Imidazoles/chemistry , Macromolecular Substances/administration & dosage , Macromolecular Substances/chemistry , Macromolecular Substances/pharmacology , Molecular Structure , Particle Size , Serine Proteinase Inhibitors/chemistry , Skin/metabolism , Skin Absorption/drug effects
18.
Icarus ; 291: 203-231, 2017 Jul 15.
Article in English | MEDLINE | ID: mdl-30393391

ABSTRACT

A high density of REMS wind measurements were collected in three science investigations during MSL's Bagnold Dunes Campaign, which took place over ~80 sols around southern winter solstice (Ls~90°) and constituted the first in situ analysis of the environmental conditions, morphology, structure, and composition of an active dune field on Mars. The Wind Characterization Investigation was designed to Available online 14 December 2016 fully characterize the near-surface wind field just outside the dunes and confirmed the primarily upslope/downslope flow expected from theory and modeling of the circulation on the slopes of Aeolis Mons in this season. The basic pattern of winds is 'upslope' (from the northwest, heading up Aeolis Mons) during the daytime (~09:00-17:00 or 18:00) and 'downslope' (from the southeast, heading down Aeolis Mons) at night (~20:00 to some time before 08:00). Between these times the wind rotates largely clockwise, giving generally westerly winds mid-morning and easterly winds in the early evening. The timings of these direction changes are relatively consistent from sol to sol; however, the wind direction and speed at any given time shows considerable intersol variability. This pattern and timing is similar to predictions from the MarsWRF numerical model, run at a resolution of ~490 m in this region, although the model predicts the upslope winds to have a stronger component from the E than the W, misses a wind speed peak at ~09:00, and under-predicts the strength of daytime wind speeds by ~2-4 m/s. The Namib Dune Lee Investigation reveals 'blocking' of northerly winds by the dune, leaving primarily a westerly component to the daytime winds, and also shows a broadening of the 1 Hz wind speed distribution likely associated with lee turbulence. The Namib Dune Side Investigation measured primarily daytime winds at the side of the same dune, in support of aeolian change detection experiments designed to put limits on the saltation threshold, and also appears to show the influence of the dune body on the local flow, though less clearly than in the lee. Using a vertical grid with lower resolution near the surface reduces the relative strength of nighttime winds predicted by MarsWRF and produces a peak in wind speed at ~09:00, improving the match to the observed diurnal variation of wind speed, albeit with an offset in magnitude. The annual wind field predicted using this grid also provides a far better match to observations of aeolian dune morphology and motion in the Bagnold Dunes. However, the lower overall wind speeds than observed and disagreement with the observed wind direction at ~09:00 suggest that the problem has not been solved and that alternative boundary layer mixing schemes should be explored which may result in more mixing of momentum down to the near-surface from higher layers. These results demonstrate a strong need for in situ wind data to constrain the setup and assumptions used in numerical models, so that they may be used with more confidence to predict the circulation at other times and locations on Mars.

19.
J Nurs Manag ; 24(8): 1130-1136, 2016 Nov.
Article in English | MEDLINE | ID: mdl-27573370

ABSTRACT

AIM: A Delphi survey was undertaken to refine the position description of a registered nurse working in a forensic hospital, in New South Wales, Australia. BACKGROUND: Prior to commencing operation in 2008, position descriptions were developed from a review of legislation, as well as policies and procedures used by existing forensic mental health services in Australia. With an established workforce and an evolving model of care, a review of the initial registered nurse position description was required. METHOD: An online Delphi survey was undertaken. Eight executive (88.9%) and 12 (58.3%) senior nursing staff participated in the first survey round. A total of four survey rounds were completed. RESULTS: At the final round, there was consensus (70%) that the revised position description was either very or somewhat suitable. There were a total of nine statements, from 31 originally produced in round 1, that did not reach consensus. CONCLUSIONS: The Delphi survey enabled a process for refining the Forensic Hospital registered nurse position description. IMPLICATIONS FOR NURSING MANAGEMENT: Methods that facilitate executive and senior nursing staff consensus in the development and review of position descriptions should be considered in nursing management.


Subject(s)
Consensus , Forensic Nursing/methods , Job Description , Mental Health Services , Nurse's Role , Adult , Delphi Technique , Female , Humans , Male , Mental Health Services/standards , Middle Aged , New South Wales , Surveys and Questionnaires , Workforce
20.
Dementia (London) ; 15(5): 1219-33, 2016 Sep.
Article in English | MEDLINE | ID: mdl-25394555

ABSTRACT

There are currently no internationally recognised and approved processes relating to the care of older persons with dementia in prison. This research aimed to develop tools and procedures related to managing the care of, including the identification and assessment of, older persons with dementia who are imprisoned in New South Wales, Australia. A modified approach to the Policy Delphi method, using both surveys and facilitated discussion groups, enabled experts to come together to discuss improving the quality of care provision for older persons with dementia in prison and achieve research aims.


Subject(s)
Attitude of Health Personnel , Criminals/psychology , Dementia/diagnosis , Dementia/therapy , Health Services Needs and Demand , Prisons/standards , Aged , Aged, 80 and over , Australia , Delphi Technique , Health Personnel , Humans , Middle Aged
SELECTION OF CITATIONS
SEARCH DETAIL
...